2025年

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当前所在位置：首页科学研究论文发表 2025年

1.CD47-blocking antibody confers metabolic benefits against obesity.

Su Y, Sun J, Li X, Huang F, Kong Y, Chen Z, Zhang J, Qin D, Chen X, Wang Z, Pei Y, Gong M, Yang K, Xu M, Dong Y, He Q, Zhang ZN, Sheng Z, Deng Q, Wang H, Wang G, Hu P, Le R, Gao S, Li W. CD47-blocking antibody confers metabolic benefits against obesity. Cell Rep Med. 2025 May 20;6(5):102089. doi: 10.1016/j.xcrm.2025.102089. Epub 2025 Apr 22. PMID: 40267910; PMCID: PMC12147847.

2.Acetylation at lysine 27 on maternal H3.3 regulates minor zygotic genome activation.

Zhang J, Li X, Zhao Q, Ji J, Cui H, Hou W, Wang X, Song E, Xiao S, Ling S, Gao S, Liu X, Wen D, Kong Q. Acetylation at lysine 27 on maternal H3.3 regulates minor zygotic genome activation. Cell Rep. 2025 Jan 28;44(1):115148. doi: 10.1016/j.celrep.2024.115148. Epub 2024 Dec 31. PMID: 39932187; PMCID: PMC11892348.

3.Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA.

Zhang X, Xu R, Zhao Y, Yang Y, Shi Q, Wang H, Liu X, Gao S, Li C. Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA. Protein Cell. 2025 Feb 13:pwaf010. doi: 10.1093/procel/pwaf010. Epub ahead of print. PMID: 39945726.

4.Core factor of NEXT complex, ZCCHC8, governs the silencing of LINE1 during spermatogenesis.

Yan R, Qi M, Zhang P, Shen B, Yin J, Chen C, Tian S, Chen L, Huang X, Wang H, Gao S, Wu Y, Gao Y. Core factor of NEXT complex, ZCCHC8, governs the silencing of LINE1 during spermatogenesis. Natl Sci Rev. 2024 Dec 17;12(1):nwae407. doi: 10.1093/nsr/nwae407. PMID: 39758125; PMCID: PMC11697976.

5.Maternal infection with SARS-CoV-2 during early pregnancy induces hypoxia at the maternal-fetal interface.

Shi X, Xi C, Dong B, Yan Z, Liu W, Gao S, Chen D. Maternal infection with SARS-CoV-2 during early pregnancy induces hypoxia at the maternal-fetal interface. Cell Prolif. 2025 Feb;58(2):e13749. doi: 10.1111/cpr.13749. Epub 2024 Oct 7. PMID: 39375953; PMCID: PMC11839197.

6.Inhibition of aging-induced DNA hypermethylation by si-Dnmt3a/3b in pre-implantation embryos improves aberrant social behavior in offspring.

Liu YD, Teng XM, Bai DD, Xing FY, Chang QR, Li JL, Gao SR, Liu WQ, Guo Y. Inhibition of aging-induced DNA hypermethylation by si-Dnmt3a/3b in pre-implantation embryos improves aberrant social behavior in offspring. Int J Biol Macromol. 2025 May;307(Pt 4):142130. doi: 10.1016/j.ijbiomac.2025.142130. Epub 2025 Mar 17. PMID: 40107549.

7.Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification.

Xu R, Li Y, Wu Y, Liu X, Gao S. Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification. Trends Genet. 2025 Jun 5:S0168-9525(25)00112-X. doi: 10.1016/j.tig.2025.05.005. Epub ahead of print. PMID: 40480920.

8.Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism.

Jia Y, Liu Y, Li Y, Guan X, Xu J, Yan Z, Liu K, Zhang Y, Bai D, Xiang J, Zhang Y, Hou S, Kou X, Zhao Y, Yin J, Wang H, Li K, Gao S, Liu W. Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism. Sci Bull (Beijing). 2025 May 8:S2095-9273(25)00472-4. doi: 10.1016/j.scib.2025.05.003. Epub ahead of print. PMID: 40441968.

9.Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation.

Cui X, Dong Y, Zhan Q, Huang Y, Zhu Q, Zhang Z, Yang G, Wang L, Shen S, Zhao J, Lin Z, Sun J, Su Z, Xiao Y, Zhang C, Liang Y, Shen L, Ji L, Zhang X, Yin J, Wang H, Chen Z, Ju Z, Jiang C, Le R, Gao S. Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation. Sci China Life Sci. 2025 May;68(5):1209-1225. doi: 10.1007/s11427-024-2754-9. Epub 2024 Dec 27. PMID: 39754007.

10.CD47-blocking antibody confers metabolic benefits against obesity.

https://mp.weixin.qq.com/s/Wdum-YruIEJqs4MXrUQbeQ

11.Setd2 overexpression rescues bivalent gene expression during SCNT-mediated ZGA.

https://mp.weixin.qq.com/s/z6u4thHUCb5WJvDbWH_kiw

12.Core factor of NEXT complex, ZCCHC8, governs the silencing of LINE1 during spermatogenesis.

https://mp.weixin.qq.com/s/CSbZV8Aym7Blq3LCCVw2RA

13.Maternal infection with SARS-CoV-2 during early pregnancy induces hypoxia at the maternal-fetal interface.

https://mp.weixin.qq.com/s/rlJ9pZMGqdahewZzYiL2DA

14.Persistent Wnt signaling affects IVF embryo implantation and offspring metabolism.

https://mp.weixin.qq.com/s/h5LZFRjM7DRq30lxKR81bQ

15.Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation.

https://mp.weixin.qq.com/s/7nBld4oDkMnBLlkyomMF4A

16.Integrative deep learning of spatial multi-omics with SWITCH

Li Z, Qu S, Liang H, Tang R, Zhang X, Lu F, Yang J, Gan Z, Gao S, Zhang Y, Chen G. Integrative deep learning of spatial multi-omics with SWITCH. Nat Comput Sci. 2025 Nov;5(11):1051-1063. doi: 10.1038/s43588-025-00891-w. Epub 2025 Oct 29. PMID: 41162770.

https://mp.weixin.qq.com/s/kq4tBDUC0LiX-J1FnZ2eCQ

17.N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells

Zhu X, Chang Z, Xiao W, Zhang X, Ma M, Wu J, Hu J, Bi Y, Kou X, Zhao Y, Sheng Y, Dong B, Sun J, Chen C, Wu Y, Liu X, Ding W, Jia K, Yao Y, Sun L, Yu X, Wang H, Liu J, Wang Y, Gao S, Gao Y. N6-methyladenosine on L1PA governs the trans-silencing of LTRs and restrains totipotency in naive human embryonic stem cells. Cell Stem Cell. 2025 Nov 6;32(11):1773-1791.e13. doi: 10.1016/j.stem.2025.10.003. Epub 2025 Oct 29. PMID: 41167193.

https://mp.weixin.qq.com/s/9lzAiBmxDClgmisdV0A4Ng

18.Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke

Wu H, Liu Z, Zhang Z, Liu Z, Gao Z, Mamtilahun M, Li H, Li Y, Wu S, Tang G, Yang GY, Li W, Gao S, Wang M. Injectable micropore-forming microgel scaffold for neural progenitor cells transplantation and vascularization after stroke. Nat Commun. 2025 Oct 23;16(1):9285. doi: 10.1038/s41467-025-64240-1. PMID: 41130961; PMCID: PMC12549824.

https://mp.weixin.qq.com/s/VkdY4gJcKG5dHC1WVGFRfQ

19.Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells

Yang L, Di A, Song L, Liu X, Wu D, Wang S, Hao Z, Bu L, Bai C, Su G, Wei Z, Zhang L, Liu Z, Gao S, Li G. Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells. Nat Biotechnol. 2025 Oct 7. doi: 10.1038/s41587-025-02832-4. Epub ahead of print. PMID: 41057660.

https://mp.weixin.qq.com/s/Gzc-GqZVNzvLc5oQDDvjlQ

20.Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis

Li Y, He J, Liu Y, Hui Y, Liu S, Zhang Y, Xiong Y, Xu T, Xu Z, Zhang Z, Zhang Y, Yang G, Zhao J, Bai D, Lei X, Kou X, Zhao Y, Du J, Guo Z, Yin J, Zhang X, Xu C, Gao Y, Chen M, Wang H, Jiang C, Gao S, Liu W. Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis. Nat Cell Biol. 2025 Oct;27(10):1797-1811. doi: 10.1038/s41556-025-01776-w. Epub 2025 Oct 1. PMID: 41034520.

https://mp.weixin.qq.com/s/EBLoiDIq5xc5ocxNhiEeTQ

21.PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability

Zhang D, Tang Y, Ye W, Yang D, Qin S, Liu J, et al. PKM1 is required for embryonic cardiomyocyte proliferation through energetic regulation of NFYa stability. National Science Review. 2025. doi: 10.1093/nsr/nwaf408.

https://mp.weixin.qq.com/s/RnN8i-aPHkq_4D8kcMZJrw

22. Modeling post-gastrula development via bidirectional pluripotent stem cells

Liu K, Yan Z, Bai D, Jiang R, Bi Y, Ma X, et al. Modeling post-gastrula development via bidirectional pluripotent stem cells. Cell Res. 2025;35(12):954-69. doi: 10.1038/s41422-025-01172-x.

https://mp.weixin.qq.com/s/HSNf4B5xkSeZXNCJ5Zop-g

23.F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair

Xu X, Gao F, Chen Q, Chen B, Liang W, Huang R, Liu Y, Liu Z, Zhu Y, Lin G, Ma B, Yang L, Gao S, Zhu R, Cheng L. F-box/LRR-repeat protein 12 reorchestrated microglia to inhibit scarring and achieve adult spinal cord injury repair. Signal Transduction and Targeted Therapy. 2025;10(1):259. doi: 10.1038/s41392-025-02354-0.

https://mp.weixin.qq.com/s/ufFm_oogAGN14UPFULsfng

24.Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq

Wang H, Wu A, Yang MC, Zhou D, Chen X, Shi Z, Zhang Y, Liu YX, Chen K, Wang X, Cheng XF, He B, Fu Y, Kang L, Hou Y, Chen K, Bian S, Tang J, Xue J, Wang C, Liu X, Shi J, Gao S, Zhang J. Genome-wide investigation of transcription factor footprints and dynamics using cFOOT-seq. Protein Cell. 2025 Nov 1;16(11):932-952. doi: 10.1093/procel/pwaf071. PMID: 40795153; PMCID: PMC12698189.

https://mp.weixin.qq.com/s/J_UyauBo-th9mA_kV0nv5g

25.Intercellular crosstalk within human preimplantation lineages regulates trophectoderm specification

25.Tu Z, Bi Y, Lin T, Wu T, Wang H, Li J, Huang G, Gao S, Wang Y. Intercellular crosstalk within human preimplantation lineages regulates trophectoderm specification. Sci Bull (Beijing). 2025 Nov 15;70(21):3484-3488. doi: 10.1016/j.scib.2025.06.003. Epub 2025 Jun 7. PMID: 40562650.

https://mp.weixin.qq.com/s/UmDSSLbAIvm3vX5Ge5UKgQ

26.Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability

Bi Y, Hu J, Wu T, Ouyang Z, Lin T, Sun J, Zhang X, Xu X, Wang H, Wei K, Gao S, Wang Y. Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability. Protein Cell. 2025 Oct 31;16(10):858-872. doi: 10.1093/procel/pwaf053. PMID: 40578838; PMCID: PMC12578290.

https://mp.weixin.qq.com/s/2sDjV002hAP-_mZjjqrR0g