1. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. 

Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. 

Science. 2022 May 27;376(6596):968-973. doi: 10.1126/science.abe9582. Epub 2022 May 5. 

2. Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos. 

Xu R, Li S, Wu Q, Li C, Jiang M, Guo L, Chen M, Yang L, Dong X, Wang H, Wang C, Liu X, Ou X, Gao S. 

Cell Stem Cell. 2022 Jul 7;29(7):1051-1066.e8. doi: 10.1016/j.stem.2022.06.001. Cover paper

3. N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. 

Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S. 

Nat Cell Biol. 2022 Jun;24(6):917-927. doi: 10.1038/s41556-022-00915-x. 

4. Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo. 

Yang H, Bai D, Li Y, Yu Z, Wang C, Sheng Y, Liu W, Gao S, Zhang Y.

Nat Cell Biol. 2022 May;24(5):783-792. doi: 10.1038/s41556-022-00900-4. 

5. Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation.

Wang C, Chen C, Liu X, Li C, Wu Q, Chen X, Yang L, Kou X, Zhao Y, Wang H, Gao Y, Zhang Y, Gao S. 

Cell Res. 2022 Sep;32(9):801-813. doi: 10.1038/s41422-022-00652-8. Cover paper

6. Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos.

Li J, Zhang J, Hou W, Yang X, Liu X, Zhang Y, Gao M, Zong M, Dong Z, Liu Z, Shen J, Cong W, Ding C, Gao S, Huang G, Kong Q.

Cell Discov. 2022 Sep 27;8(1):96. doi: 10.1038/s41421-022-00440-z.

7. Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures. 

Bi Y, Tu Z, Zhou J, Zhu X, Wang H, Gao S, Wang Y. 

Nat Commun. 2022 Jun 7;13(1):3147. doi: 10.1038/s41467-022-30924-1. 

8. BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding. 

Wang M, Zhao K, Liu M, Wang M, Qiao Z, Yi S, Jiang Y, Kou X, Zhao Y, Yin J, Li T, Wang H, Jiang C, Gao S, Chen J. 

Protein Cell. 2022 Aug;13(8):580-601. doi: 10.1007/s13238-021-00896-x. Cover paper

9. Bilineage embryo-like structure from EPS cells can produce live mice with tetraploid trophectoderm. 

Kuisheng Liu; Xiaocui Xu; Dandan Bai; Yanhe Li; Yalin Zhang; Yanping Jia; Mingyue Guo; Xiaoxiao Han; Yingdong Liu; Yifan Sheng; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Sheng Liu; Jiayu Chen; Hong Wang; Yixuan Wang; Wenqiang Liu; Shaorong Gao. 

Protein & Cell. 2022.

10. Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs. 

Kun Zhao; Xiaoxiang Sun; Caihong Zheng; Mengting Wang; Zhu Xu; Mingzhu Wang; Jiayu Chen; Mingyue Guo; Rongrong Le; Li Wu; Yibin Wang; Xiaochen Kou; Yanhong Zhao; Jiqing Yin; Hong Wang; Zhiyong Mao; Shaorong Gao; Shuai Gao 

Science Bulletin. 2022 Jun 15;67(11):1126-1130. doi: 10.1016/j.scib.2022.04.003.

11. Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos. 

Bai D, Sun J, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C, Gao S, Liu W. 

Cell Rep. 2022 May 3;39(5):110784. doi: 10.1016/j.celrep.2022.110784. 

12. Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq. 

Yang L, Xu X, Xu R, Chen C, Zhang X, Chen M, Kou X, Zhao Y, Wang H, Liu X, Gao S, Li C. 

Stem Cell Reports. 2022 Jul 12;17(7):1730-1742. doi: 10.1016/j.stemcr.2022.05.020. 

13. Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming. 

Xi C, Sun J, Xu X, Wu Y, Kou X, Zhao Y, Shen J, Dong Y, Chen K, Su Z, Liu D, Ye W, Liu Y, Zhang R, Xu Y, Wang H, Hao L, Wu L, Gao S.

Stem Cell Reports. 2022 Aug 9;17(8):1799-1809. doi: 10.1016/j.stemcr.2022.06.012.

14. Disrupted mossy fiber connections from defective embryonic neurogenesis contribute to SOX11-associated schizophrenia. 

Abulaiti X, Wang A, Zhang H, Su H, Gao R, Chen J, Gao S, Li L. 

Cell Mol Life Sci. 2022 Mar 7;79(3):180. doi: 10.1007/s00018-022-04206-4. 

15. Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring.

Jia Y, Liu W, Bai D, Zhang Y, Li Y, Liu Y, Yin J, Chen Q, Ye M, Zhao Y, Kou X, Wang H, Gao S, Li K, Chen M.

J Pineal Res. 2022 Jan;72(1):e12778. doi: 10.1111/jpi.12778. 

16. Epigenetic regulation of cell fate transition: learning from early embryo development and somatic cell reprogramming.

Chen C, Gao Y, Liu W, Gao S.

Biol Reprod. 2022 Jul 25;107(1):183-195. doi: 10.1093/biolre/ioac087. PMID: 35526125 Free PMC article. Review.

17. Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse.

Zhao Y, Bai D, Wu Y, Zhang D, Liu M, Tian Y, Lu J, Wang H, Gao S, Lu Z.

Development. 2022 Aug 1;149(15):dev200316. doi: 10.1242/dev.200316. Epub 2022 Aug 4.

18. Zfp281 is essential for epiblast maturation through a cell autonomous effect.

Zang R, Huang X, Li D, Zhou H, Gao S, Wang J.

J Genet Genomics. 2022 Jan;49(1):85-88. doi: 10.1016/j.jgg.2021.08.016. 

19. Cancer Cells Evade Stress-Induced Apoptosis by Promoting HSP70-Dependent Clearance of Stress Granules. 

Wang A, Abulaiti X, Zhang H, Su H, Liu G, Gao S, Li L. 

Cancers (Basel). 2022 Sep 25;14(19):4671. doi: 10.3390/cancers14194671. 

20. Poly (Butylene Succinate)/Silicon Nitride Nanocomposite with Optimized Physicochemical Properties, Biocompatibility, Degradability, and Osteogenesis for Cranial Bone Repair.

Zhao Q, Gao S.

J Funct Biomater. 2022 Nov 8;13(4):231. doi: 10.3390/jfb13040231.

21. The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission.

Sun L, Ye H, Tian H, Xu L, Cai J, Zhang C, Wang R, Yang H, Zhao S, Zhang J, Gao S.

Oxid Med Cell Longev. 2022 Sep 19;2022:3639302. doi: 10.1155/2022/3639302.

22. Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells.

Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S.

Exp Mol Med. 2022 Jan;54(1):81-90. doi: 10.1038/s12276-021-00722-8.