姓名：毕焱

邮箱：biy151@163.com

教育及工作经历：

2024.3 – 至今 同济大学，生命科学与技术学院，副教授

2021.3 – 2024.2 同济大学，生命科学与技术学院，生物医学工程，博士后

2016.9 – 2021.1 同济大学，生命科学与技术学院，生物学，理学博士

2012.9 – 2016.6 郑州大学，生命科学与技术学院，生物技术，理学学士

研究方向：

1.人naïve态建立、维持及调控分子作用机制研究；

2.人的类胚胎模型体外构建及应用研究。

发表文章：

[1] Bi Y *, Tu Z *, Zhou J, Zhu X, Wang H, Gao S, and Wang Y (2022). Cell fate roadmap of human primed-to-naive transition reveals preimplantation cell lineage signatures. 

Nature Communications 13 (2022).

[2] Bi Y*, Tu Z*, Zhang Y, Yang P, Guo M, Zhu X, Zhao C, Zhou J, Wang H, Wang Y, Gao S. Identification of ALPPL2 as a Naïve Pluripotent State-Specific Surface Protein Essential for Human Naïve Pluripotency Regulation. 

Cell Reports. 2020 Mar 17;30(11):3917-3931.e5.

[3] Tu Z*, Bi Y*, Zhu X, Liu W, Hu J, Wu L, Mao T, Zhou J, Wang H, Gao S, and Wang Y. Modeling human pregastrulation development by 3D culture of blastoids generated from primed-to-naive transitioning intermediates. 

Protein Cell 14, 337-349, doi:10.1093/procel/pwac041 (2023).

[4] Tu Z*, Bi Y*, Mao T, Wang H, Gao S, Wang Y. Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naive pluripotency transition process.

Cell Regeneration 12, 35, doi:10.1186/s13619-023-00179-2 (2023).

[5] Guo M*, Zhang Y*, Zhou J, Bi Y, Xu J, Xu C, Kou X, Zhao Y, Li Y, Tu Z, Liu K, Lin J, Yang P, Gao S, Wang Y. Precise temporal regulation of Dux is important for embryo development. Cell Res. 2019 Nov;29(11):956-959.

[6] Wang Y*, Zhao C*, Hou Z*, Yang Y*, Bi Y, Wang H, Zhang Y, Gao S. Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state. Elife. 2018 Jan 30;7:e29518.

[7] Wang Y, Bi Y, Gao S. Epigenetic regulation of somatic cell reprogramming. Curr Opin Genet Dev. 2017 Oct;46:156-163.