个人简介：

      主要从事早期胚胎发育和人辅助生殖研究。在胚胎发育及表观遗传方面积累了丰富的经验。近年来主持国家自然科学基金1项、上海市课题3项，发表 SCI 论文 10 余篇。其以第一作者（兼共同）在 Nature，Cell Reports，Cell Discovery，Human Genetics 等知名学术期刊发表论文6 篇，并参与多个课题研究工作，主要研究成果包括：

1．以共同第一作者在 Nature 报道了哺乳动物早期胚胎发育过程中组蛋白H3K4me3 和HK27me3 修饰建立模式，对研究胚胎发育异常，提高早期胚胎发育潜能具有重要意义。同期 Nature 配发了专门评述，并入选中国科协2016年度“中国生命科学领域十大进展”。

2．首次利用单细胞表观组学揭示了导致克隆胚胎发育阻滞的分子机制(Cell Discovery),为临床上胚胎发育阻滞研究提供了新的思路。发现重编程因子在受精后选择性地集中在雄原核中(Cell Repoerts)，为以后研究合子发育及雌雄原核重编程提供了基础。

3．在辅助生殖临床治疗方面首次揭示透明带蛋白ZP2、ZP3双杂合突变导致女性不育的机制，并使患者成功产下健康男婴(Human Genetics)，为临床中透明带异常患者的治疗提供了新的思路及治疗手段。利用纺锤体观测技术在临床体外受精早期准确分辨未受精卵，并及早进行单精子注射补救，提高了体外受精患者的受精成功率 (Fertility and Sterility)。

发表论文

1. Xiaoyu Liu#, Chenfei Wang#, Wenqiang Liu#, Jingyi Li#, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang*, Yawei Gao*&Shaorong Gao*. Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos.Nature, 2016, 537, 558–562 (#co-first authors)

2.Wenqiang Liu#, Xiaoyu Liu#, Chenfei Wang#, Yawei Gao#*, Rui Gao, Xiaochen Kou, Yanhong Zhao, Jingyi Li, You Wu, Wenchao Xiu, Su Wang, Jiqing Yin, Wei Liu, Tao Cai, Hong Wang, Yong Zhang*, Shaorong Gao*. Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing. Cell Discovery, 2016, 2：16010(#co-first authors)

3. Wenqiang Liu#, Kunming Li#, Dandan Bai#, Jiqing Yin#, Yuanyuan Tang, Fengli Chi, Linfeng Zhang, Yu Wang, Jiaping Pan, Shanshan Liang, Yi Guo, Jingling Ruan, Xiaochen Kou, Yanhong Zhao, Hong Wang, Jiayu Chen*, Xiaoming Teng*, Shaorong Gao*. Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility. Human Genetics, 2017, 136 (8), 975-985 (#co-first authors)

4. Yi Guo#, Wen qiang Liu#, Yu Wang, Jiaping Pan, Shanshan Liang, Jingling Ruan, Xiaoming Teng*. Polarization microscopy imaging for the identification of unfertilized oocytes following short-term insemination. Fertility and Sterility, 2017, 108 (1), 78-83 (#co-first authors)  

5. Wenqiang Liu, Jiqing Yin, Xiaochen Kou, Yonghua Jiang, Haibo Gao, Yanhong Zhao, Bo Huang, Wenteng He, Hong Wang, Zhiming Han*, and Shaorong Gao* Asymmetric reprogramming capacity of parental pronuclei in mouse zygotes. Cell reports, 2014, 6 (6): 1008-1016

6. Wenqiang Liu, Jiqing Yin, Guimin Zhao, Yan Yun, Shujun Wu, Jones K.T.,

and Anmin Lei*. Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes.Theriogenology, 2012, 78, 1171-1181

7. Shuai Gao#, Caihong Zheng#, Gang Chang#, Wenqiang Liu, Xiaochen Kou, Kun Tan, Li Tao, Kai Xu, Hong Wang, Jun Cai*, Jianhui Tian*, Shaorong Gao* Unique features of mutations revealed by sequentially reprogrammed induced pluripotentstem cells. Nature Communications, 2015,6:6318..

8. Rongrong Le, Zhaohui Kou, Yonghua Jiang, Ming Li, Bo Huang, Wenqiang Liu, Hui Li, Xiaochen Kou, Wanzhong He, Karl Lenhard Rudolph, Zhenyu Ju* and Shaorong Gao*. Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. Cell stem cell, 2014, 14 (1): 27-39

9. Gang Chang#, Shuai Gao#, Xinfeng Hou, Zijian Xu, Yanfeng Liu, Lan Kang, Yu Tao, Wenqiang Liu, Bo Huang, Xiaochen Kou, Jiayu Chen, Lei An, Kai Miao, Keqian Di, Zhilong Wang, Kun Tan, Tao Cheng, Tao Cai, Shaorong Gao*, Jianhui Tian*. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells. Cell Research, 2014, 24 (3): 293-306

10. Yawei Gao#, Jiayu Chen#, Ke Li, Tong Wu, Bo Huang, Wenqiang Liu, Xiaochen Kou, Yu Zhang, Hua Huang, Yonghua Jiang, Chao Yao, Xiaolei Liu, Zhiwei Lu, Zijian Xu, Lan Kang, Jun Chen, Hailin Wang, Tao Cai* and Shaorong Gao*. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell, 2013, 12 (4): 453-469