姓       名：高睿

学       位：博士

研究领域：胚胎发育和表观遗传

研究方向：

1. 原始生殖细胞及早期胚胎发育的调控机制

2. 生殖细胞及胚胎发育异常的机制及干预

E-mail：gaorui@tongji.edu.cn

实验室网站：https://gaolab.tongji.edu.cn/main.htm

通讯地址：上海市四平路1239号，同济大学生命科学与技术学院（200092）

个人简介：

2008.9—2012.7      北京师范大学  生命科学与技术学院  学士

2012.9—2017.6      清华大学生命学院，北京生命科学研究所  博士

2017.6—2020.5      同济大学  生命科学与技术学院  博士后

2020.5—2023.12     同济大学 生命科学与技术学院  预聘助理教授

2023.12至今        同济大学 生命科学与技术学院  预聘副教授

高睿博士，现于高绍荣院士、陈嘉瑜教授团队，主要研究方向为人类生殖健康的表观遗传调控机制，解析配子发生及早期胚胎发育过程中表观遗传重塑的生理基础，阐明导致配子及胚胎发育缺陷的表观遗传修饰病理退变，为维持及提升人类配子及早期胚胎健康发育提供新思路和新方法，以第一或通讯（含共同）作者在Cell Stem Cell、Developmental Cell等国际知名学术期刊发表SCI论文11篇，授权中国发明专利2项。主持国自然项目2项，上海市科委项目1项，以组长和骨干参与科技部重点研发计划各1项，获博新计划等省部级人才项目支持。

发表论文：

#第一作者 *通讯作者

1.Gao R#,*, Yang G#, Wang M#, Xiao J#, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S*, Jiang C*, Chen J*. Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Developmental Cell. 2024, doi: 10.1016/j.devcel.2024.03.015.

2.Shen S#, Wang M#, Li X#,*, Wang B#, Hong W#, Li W, Xu B, Guo Z, Han R, Yi S, Wu Z, He X, Wang L, Zhu Q, Yang G, Wang H, Deng Q, Chen J*, Gao S*, Jiang C*, Gao R*. The Ggonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection. Cell Reports Medicine. 2024, doi: 10.1016/j.xcrm.2024.101515.

3.Wang L#, Yi S#, Cui X#, Guo Z, Wang M, Kou X, Zhao Y, Wang H, Jiang C, Gao S*, Yang G*, Chen J*, Gao R*. Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification. Cell Reports. 2024, doi: 10.1016/j.celrep.2024.114136.

4.Wang W#, Gao R#, Yang D#, Ma M#, Zang R, Wang X, Chen C, Kou X, Zhao Y, Chen J, Liu X, Lu J, Xu B, Liu J, Huang Y, Chen C, Wang H, Gao S*, Zhang Y*, Gao Y*. ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice. Genes & Development. 2024, doi: 10.1101/gad.351189.123.

5.Gao R#, Zeng S#, Yang D#, Li X#, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S*, Zhang Y*, Chen J*. Resetting histone modifications during human prenatal germline development. Cell Discovery. 2023 Feb 3;9(1):14. doi: 10.1038/s41421-023-00519-1.

6.Liu W#, Chen C, Gao Y, Cui X, Zhang Y, Gu L, He Y, Li J, Gao S, Gao R*, Jiang C*. Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development. Genomics, Proteomics & Bioinformatics. 2023, doi: 10.1093/gpbjnl/qzad001.

7.Sun J#, Zheng W#, Liu W, Kou X, Zhao Y, Liang Z, Wang L, Zhang Z, Xiao J, Gao R*, Gao S*, Jiang C*. Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos, Frontiers in Cell and Developmental Biology. 2021, 9.

8.Gao H#, Gao R#, Zhang L#, Xiu W, Zang R, Wang H, Zhang Y, Chen J*, Gao Y*, Gao S*. Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs. Journal of Molecular Cell Biology. 2019 Jun 1;11(6):463-473. doi: 10.1093/jmcb/mjy054.

9.Gao R#, Wang C#, Gao Y#, Xiu W, Chen J, Kou X, Zhao Y, Liao Y, Bai D, Qiao Z, Yang L, Wang M, Zang R, Liu X, Jia Y, Li Y, Zhang Y, Yin J, Wang H, Wan X, Liu W*, Zhang Y*, Gao S*. Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos. Cell Stem Cell. 2018, 3(23): 426.

10.Gao R#, Xiu W#, Zhang L, Zang R, Yang L, Wang C, Wang M, Wang M, Yi L, Tang Y, Gao Y, Wang H, Xi J, Liu W, Wang Y, Wen X, Yu Y, Zhang Y, Chen L*, Chen J*, Gao S*. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state. Biomaterials. 2017 Mar;119:53-67.

11.Gao R#, Liu X, Gao S*. Progress in understanding epigenetic remodeling during induced pluripotency, Science Bulletin. 2015, 60(20): 1713-1721.