姓名：赵堃

邮箱：jyzhaokun12@tongji.edu.cn

教育经历：

2022.7-至今同济大学，生命科学与技术学院，生物学，博士后

2016.9-2022.6同济大学，生命科学与技术学院，生物学，理学博士

2012.9-2016-6同济大学，生命科学与技术学院，生物学，理学学士

研究方向：

iPSC、ESC基因组稳定性的维持与保护；早期胚胎发育过程中的表观修饰调控。

发表文章：

[1]Zhao K*, Sun X, Zheng C, et al. Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs. Science Bulletin. 2022, 67(11), 1126-1130

[2]Wang M, Zhao K*, Liu M, et al. Bmp4 preserves the developmental potential of mESCs through ube2s- and chmp4b-mediated chromosomal stability safeguarding. Protein Cell, 2022, 13(8), 580–601

[3]Zhao K*, Wang M, Gao S, et al. Chromatin architecture reorganization during somatic cell reprogramming. Current Opinion in Genetics & Development, 2021, 70: 104-113

[4]Yang G, Zhang L, Liu W, et al. Dux-mediated corrections of aberrant h3k9ac during 2-cell genome activation optimize efficiency of somatic cell nuclear transfer. Cell Stem Cell, 2021, 28: 150-163 e155

[5]Gao S, Tao L, Hou X, et al. Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells. Stem Cell Res Ther, 2016, 7: 40

[6]Xu K, Chen X, Yang H, et al. Maternal sall4 is indispensable for epigenetic maturation of mouse oocytes. J Biol Chem, 2017, 292: 1798-1807

[7]He W, Zhang X, Zhang Y, et al. Reduced self-diploidization and improved survival of semi-cloned mice produced from androgenetic haploid embryonic stem cells through overexpression of dnmt3b. Stem Cell Rep, 2018, 10: 477-493

[8]Wu L, He S, Ye W, et al. Surf4 facilitates reprogramming by activating the cellular response to endoplasmic reticulum stress. Cell Prolif, 2021, 54: e13133