姓名：李延鹤   

学位：博士              

邮箱：liyanhe1212@163.com

研究方向：

1.哺乳动物围着床期胚胎发育过程中的表观调控机制

2.核移植胚胎异常发育的表观重编程分子机制

3.基因编辑及表观编辑技术的建立和优化

个人简介：

2024.3至今   同济大学，生命科学与技术学院， 预聘副教授

2021.3-2024.3 同济大学，生物医学工程，博士后

2017.9-2021.3 同济大学，生命科学与技术学院，博士

2014.9-2017.6 西北农林科技大学，动物医学院，硕士

2010.9-2014.6 青岛农业大学，动物科技学院，学士

李延鹤博士，现工作于高绍荣院士、刘文强教授团队，主要聚焦于早期胚胎发育与表观调控机制相关研究。个人代表性成果发表于《Nature Cell Biology》、《Nature Communications》、《National Science Review》等国际知名学术期刊。主持国家自然科学基金青年项目、博士后面上项目（结题）。曾获得中国博士后创新人才支持计划、上海市“超级博士后”资助。

发表论文：

*第一作者/共同第一作者

1.  Li Y*, Zheng C*, Liu Y, He J, Zhang Q, Zhang Y, Kou X, Zhao Y, Liu K, Bai D, Jia Y, Han X, Sheng Y, Yin J, Wang H, Gao S, Liu W, Gao S. Inhibition of Wnt activity improves peri-implantation development of somatic cell nuclear transfer embryos. National Science Review. 2023 Aug 16;10(9): nwad173.

2．Li Y*，Weng Y，Bai D, Jia Y, Liu Y, Zhang Y, Kou X, Zhao Y, Ruan J, Chen J, Yin J, Wang H, Teng X, Wang Z, Liu W, Gao S. Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation. Nature Communications. 2020 Sep 14; 11(1): 0-4593.

3. Yang H*, Bai D*, Li Y*, Yu Z*, Wang C, Sheng Y, Liu W, Gao S, Zhang Y. Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo. Nature Cell Biology. 2022 May; 24(5): 783-792.

4. Wang Y, Li Y*, Luan D, Kang J, He R, Zhang Y, Quan F. Dynamic replacement of H3.3 affects nuclear reprogramming in early bovine SCNT embryos. Theriogenology. 2020 Sep 15; 154:43-52. 

5. Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, Dou X, Liu J, Zou Z, Cui XL, Zhang LS, Zhao X, Liu Q, He PC, Sepich-Poore C, Zhong N, Liu W, Li Y, Kou X, Zhao Y, Wu Y, Cheng X, Chen C, An Y, Dong X, Wang H, Shu Q, Hao Z, Duan T, He YY, Li X, Gao S, Gao Y, He C. FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science. 2022 May 27;376(6596):968-973. 

6. Wu Y, Xu X, Qi M, Chen C, Li M, Yan R, Kou X, Zhao Y, Liu W, Li Y, Liu X, Zhang M, Yi C, Liu H, Xiang J, Wang H, Shen B, Gao Y, Gao S. N6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition. Nature Cell Biology. 2022 Jun;24(6):917-927.

7. Chen M, Zhu Q, Li C, Kou X, Zhao Y, Li Y, Xu R, Yang L, Yang L, Gu L, Wang H, Liu X, Jiang C, Gao S. Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos. Nat Communications. 2020 Apr 14;11(1):1813. 

8. Bai D, Sun J, Chen C, Jia Y, Li Y, Liu K, Zhang Y, Yin J, Liu Y, Han X, Ruan J, Kou X, Zhao Y, Wang H, Wang Z, Chen M, Teng X, Jiang C, Gao S, Liu W. Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue cause placental defects and implantation failure in mouse IVF embryos. Cell Reports. 2022 May 3;39(5):110784.

9. Jia Y, Liu W, Bai D, Zhang Y, Li Y, Liu Y, Yin J, Chen Q, Ye M, Zhao Y, Kou X, Wang H, Gao S, Li K, Chen M. Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring. J Pineal Res. 2022 Jan;72(1): e12778. doi: 10.1111/jpi.12778. Epub 2021 Dec 3