姓名：王明珠    

邮箱：1810526@tongji.edu.cn

教育经历：

2022.6-至今        同济大学，生命科学与技术学院，生物医学工程，博士后

2016.9-2022.6       同济大学，生命科学与技术学院，生物学，理学博士

2012.9-2016.6       河南大学，生命科学与技术学院，生物技术，理学学士

研究方向：

1. 基因组稳定性调控细胞多能性的分子机制研究。

2. DNA损伤修复与表观遗传协同调控体细胞核移植胚胎发育潜能的分子机制研究。

发表文章：

[1] Wang, M.#, Zhao, K.#, Liu, M. #, Wang, M., Qiao, Z., Yi, S., Jiang, Y., Kou, X., Zhao, Y., Yin, J., Li, T., Wang, H., Jiang, C.*, Gao, S.* and Chen, J*. BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding [J]. Protein Cell, 2022. 13(8): 580-601.

[2] Zhao, K.#, Wang, M.#, Gao, S.* and Chen, J*. Chromatin architecture reorganization during somatic cell reprogramming [J]. Curr Opin Genet Dev, 2021. 70: 104-114.

[3] Zhao, K.#, Sun, X.#, Zheng, C.#, Wang, M., Xu, Z., Wang, M., Chen, J., Guo, M., Le, R., Wu, L., Wang, Y., Kou, X., Zhao, Y., Yin, J., Wang, H., Mao, Z.*, Gao, S.* and Gao, S*. Enhancement of Xrcc1-mediated base excision repair improves the genetic stability and pluripotency of iPSCs [J]. Science Bulletin, 2022. 67(11): 1126-30.

[4] Yang, G.#, Zhang, L.#, Liu, W.#, Qiao, Z., Shen, S., Zhu, Q., Gao, R., Wang, M., Wang, M., Li, C., Liu, M., Sun, J., Wang, L., Liu, W., Cui, X., Zhao, K., Zang, R., Chen, M., Liang, Z., Wang, L., Kou, X., Zhao, Y., Wang, H., Wang, Y., Gao, S., Chen, J.*, and Jiang, C*. Dux-Mediated Corrections of Aberrant H3K9ac during 2-Cell Genome Activation Optimize Efficiency of Somatic Cell Nuclear Transfer [J]. Cell Stem Cell, 2020. 28: 1-14. 

[5] Wu, Y.#, Liu, W.#, Chen, J., Liu, S., Wang, M., Yang, L., Chen, C., Qi, M., Xu, Y., Qiao, Z., Yan, R., Kou, X., Zhao, Y., Shen, B., Yin, J., Wang, H., Gao, Y.* and Gao, S*. Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells [J]. Cell Rep, 2019. 29(8): 2461-2472 e6.

[6] Li, Y.#, Zhang, Z.#, Chen, J.#, Liu, W., Lai, W., Liu, B., Li, X., Liu, L., Xu, S., Dong, Q., Wang, M., Duan, X., Tan, J., Zheng, Y., Zhang, P., Fan, G., Wong, J., Xu, G., Wang, Z., Wang, H., Gao, S. and Zhu, B*. Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1 [J]. Nature, 2018. 564(7734): 136-140.

[7] Li, J.#, Shen, S.#, Chen, J.#, Liu, W., Li, X., Zhu, Q., Wang, B., Chen, X., Wu, L., Wang, M., Gu, L., Wang, H., Yin, J., Jiang, C.* and Gao, S*. Accurate annotation of accessible chromatin in mouse and human primordial germ cells [J]. Cell Res, 2018. 28(11): 1077-1089.

[8] Gao, R.#, Wang, C.#, Gao, Y.#, Xiu, W., Chen, J., Kou, X., Zhao, Y., Liao, Y., Bai, D., Qiao, Z., Yang, L., Wang, M., Zang, R., Liu, X., Jia, Y., Li, Y., Zhang, Y., Yin, J., Wang, H., Wan, X., Liu, W.*, Zhang, Y* and Gao, S*. Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos [J]. Cell Stem Cell, 2018. 23(3): 426-435 e5.

[9] He, W.#, Zhang, X.#, Zhang, Y., Zheng, W., Xiong, Z., Hu, X., Wang, M., Zhang, L., Zhao, K., Qiao, Z., Lai, W., Lv, C., Kou, X., Zhao, Y., Yin, J., Liu, W., Jiang, Y., Chen, M., Xu, R., Le, R., Li, C., Wang, H., Wan, X., Wang, H., Han, Z., Jiang, C.*, Gao, S.* and J. Chen*. Reduced Self-Diploidization and Improved Survival of Semi-cloned Mice Produced from Androgenetic Haploid Embryonic Stem Cells through Overexpression of Dnmt3b [J]. Stem Cell Reports, 2018. 10(2): 477-493.

[10] Gao, R.#, Xiu, W.#, Zhang. L.#, Zang, R., Yang, L., Wang, C., Wang, M., Wang, M., Yi, L., Tang, Y., Gao, Y., Wang, H., Xi, J., Liu, W., Wang, Y., Wen, X., Yu, Y., Zhang, Y., Chen, L.*, Chen, J.*, Gao, S*. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state [J]. Biomaterials, 2017. 119: 53-67.