姓名：陈献威

学位：博士

导师情况：博士生导师

E-mail： chenxianwei@tongji.edu.cn

研究领域：干细胞、神经退行性疾病、肿瘤免疫治疗

研究方向：

1.阿尔茨海默病大脑类器官模型的构建、发病机制的研究和治疗方法的开发。

2.多能干细胞向NK细胞、T细胞等免疫细胞分化，以及肿瘤免疫疗法的开发。

个人简介：

2023.04-至今     同济大学附属东方医院，研究员

2023.03-至今     同济大学生命科学与技术学院，特聘研究员

2022.09-2022.11     上海跃赛生物科技有限公司，研究员

2022.01-2022.09     美国希望之城国家医疗中心，Staff Scientist

2016.08-2022.01     美国希望之城国家医疗中心，博士后

2009.09-2016.07     中国科学院北京基因组研究所，理学博士

2005.07-2009.09     内蒙古大学生命科学学院，理学学士

研究方向简介：

主要从事多能干细胞（iPSC/ESC）向大脑类器官和免疫细胞的定向分化，及其在神经系统疾病和肿瘤免疫疗法研究用的应用。建立了血清暴露诱发AD的大脑类器官模型并揭示其中的分子机制；建立了人巨细胞病毒感染的大脑类器官模型并证明中和抗体可以有效预防感染。近年以第一作者（含共同）在Advanced Science，Cell Reports Medicine及Journal of Proteomics等杂志发表多篇研究论文。2022年入选上海市海外高层次人才计划。

代表性文章：

1.X Chen*, G Sun, E Tian, M Zhang, H Davtyan, TG Beach, EM Reiman, M Blurton-Jones, D Holtzman, Y Shi. Modeling sporadic Alzheimer’s disease in human brain organoids. Advanced Science 8, e2101462 (2021).

2.G Sun*, F Chiuppesi*, X Chen*, C Wang, E Tian, J Nguyen, M Kha, D Trinh, H Zhang, MC Marchetto, H Song, G Ming, FH Gage, DJ Diamond, F Wussow, Y Shi. Modeling human cytomegalovirus-induced microcephaly in human iPSC-derived brain organoids. Cell Reports Medicine 1, 100002 (2020). 

3.X Chen*, Q Yang, Z Liu, Y Shi. Chapter 2 - Human induced pluripotent stem cell–based modeling of Alzheimer’s disease, a glial perspective. Editor(s): Alexander Birbrair. In Advances in Stem Cell Biology, iPSCs for Modeling Central Nervous System Disorders, Academic Press, Volume 6, 2021, Pages 21-35. 

4.X Chen*, Y Zhu, Z Wang, H Zhu, Q Pan, S Su, Y Dong, L Li, H Zhang, L Wu, X Lou, S Liu. mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances. Journal of Proteomics 136: 13-24 (2016).

5.X Chen*, D Guo, Y Zhu, F Xian, S Liu, L Wu, X Lou. Nuclear Phosphoproteomics Analysis Revealed that CDK1/2 were Involved in EGF-Regulated Constitutive Pre-mRNA Splicing in MDA-MB-468 Cells. Journal of Proteomics 141:77-84 (2016).

6.L Li*, E Tian*, X Chen, J Chao, J Klein, Q Qu, G Sun, G Sun, Y Huang, CD Warden, P Ye, L Feng, X Li, Q Cui, A Sultan, P Douvaras, V Fossati, NE Sanjana, AD Riggs, Y Shi. GFAP mutations in astrocytes impair oligodendrocyte progenitor proliferation and myelination in an hiPSC model of Alexander disease. Cell stem cell 23 (2), 239-251. e6 (2018). 

7.Q Cui*, K Yin*, X Zhang*, P Ye, X Chen, J Chao, H Meng, J Wei, D Roeth, L Li, Y Qin, G Sun, M Zhang, J Klein, M Huynhle, C Wang, L Zhang, B Badie, M Kalkum, C He, C Yi, Y Shi. Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis. Nature Cancer 1-18 (2021).

8.C Wang*, M Zhang*, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswami, Y Shi. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response. Cell Stem Cell 28(2):331-342.e5 (2021).

9.L Feng*, J Chao*, E Tian*, L Li*, P Ye, M Zhang, X Chen, Q Cui, G Sun, T Zhou, G Felix, Y Qin, W Li, ED Meza, J Klein, L Ghoda, W Hu, Y Luo, W Dang, D Hsu, J Gold, SA Goldman, R Matalon, Y Shi. Cell‐Based Therapy for Canavan Disease Using Human iPSC‐Derived NPCs and OPCs. Advanced Science. 7 (23), 2002155 (2020).