姓名： 高亚威  

学位：博士

导师情况：博士生导师

研究领域：发育生物学，干细胞与表观遗传学

研究方向：

1．RNA与核内多重表观组学的相互作用机制。

2．早期胚胎发育与中的表观修饰变化，雌雄原核表观遗传重编程差异。

3．核移植引发的表观修饰缺陷与重编程分子机制研究。

4．配子发育的表观调控机制与转录后调控。

个人简历：

2018.03-今，    同济大学生命科学与技术学院，教授

2018.03-2018.11，芝加哥大学，访学副教授 

2015.12-2018.03，同济大学生命科学与技术学院，副教授

2014.02-2015.11，同济大学转化医学高等研究院，助理研究员

2009.9-2014.1，清华大学医学部,北京协和医学院，理学博士

2005.9-2009.6，上海交通大学生命科学技术学院，理学学士

研究方向简介：

主要从事发育、转分化、核移植和诱导重编程等过程的多层级的表观调控机制研究。2013年在cell stem cell杂志上合作发表封面文章揭示了DNA甲基化与羟甲基化介导的表观遗传重编程的分子机制，该论文被评为年度十佳论文。2014年进入同济大学工作后，建立完善了一系列全球领先的微量测序技术，首次探索了早期胚胎中多种组蛋白修饰重塑与实现转录活性调控的分子机制，揭示了组蛋白与DNA修饰异常是体细胞核移植胚胎发育的重要表观障碍，并开拓了RNA表观修饰对转录的调控机制，提出多个m6A调控相关蛋白通过LINE1 RNA的m6A修饰影响核表观与发育的分子模型。其创新性成果发表在Nature，Science，Cell Stem Cell, Nature Cell Biology等顶级杂志。成果曾获2016年度“中国生命科学十大进展”，3篇入选ESI高被引数据库。主持科技部重点研发计划青年科学家项目，国自然优青，面上，青年等项目。入选青年拔尖，“青年人才托举工程”，上海市晨光计划，青年科学启明星计划，等多个人才项目。获国家自然科学二等奖（2/5），上海市自然科学一等奖（3/5），教育部高等学校科学研究优秀成果奖（科学技术）一等奖（3/9）等。并获评中国细胞生物学会干细胞分会“干细胞卓越青年研究员”（2023），动物学会第七届青年科技奖（2017）等。

代表作论文

1. Wei, Jiangbo*; Yu, Xianbin*; Yang, Lei*; Liu, Xuelian*; Gao, Boyang; Huang, Boxian; Dou, Xiaoyang; Liu, Jun; Zou, Zhongyu; Cui, Xiao-Long; Zhang, Li-Sheng; Zhao, Xingsen; Liu, Qinzhe; He, P Cody; Sepich-Poore, Caraline; Zhong, Nicole; Liu, Wenqiang; Li, Yanhe; Kou, Xiaochen; Zhao, Yanhong; Wu, You; Cheng, Xuejun; Chen, Chuan; An, Yiming; Dong, Xueyang; Wang, Huanyu; Shu, Qiang; Hao, Ziyang; Duan, Tao; He, Yu-Ying; Li, Xuekun; Gao, Shaorong#; Gao, Yawei#; He, Chuan# FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development  Science 2022 May 27;376(6596):968-973

2.Jun Liu*, Xiaoyang Dou*, Chuanyuan Chen*, Chuan Chen, Chang Liu Meng Michelle Xu, Siqi Zhao, Bin Shen, Yawei Gao#, Dali Han#, Chuan He# N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Science 2020 Jan 31;367(6477):580-586. 

3. Xiaoyu Liu*, Chenfei Wang*, Wenqiang Liu*, Jingyi Li*, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang#, Yawei Gao# & Shaorong Gao#Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos Nature 2016 Sep 14;537(7621):558-562.

4. You Wu*, Xiaocui Xu*, Meijie Qi*, Chuan Chen, Mengying Li, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Wenqiang Li, Yanhe Li, Xuelian Liu, Meiling Zhang, Chengqi Yi, Hongbin Liu, Junhong Xiang, Hong Wang, Bin Shen#, Yawei Gao#, Shaorong Gao#

N 6-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition Nat Cell Biol 2022 Jun;24(6):917-927.

5.Wang Chenfei*, Chen Chuan*, Liu Xiaoyu*, Li Chong*, Wu Qiu, Chen Xiaolan, Yang Lingyue, Kou Xiaochen, Zhao Yanhong, Wang Hong, Gao Yawei#, Zhang Yong#, Gao Shaorong# Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation. Cell Research (2022) 32, 801–813. 封面论文

6. Wen Wang; Rui Gao; Dongxu Yang; Mingli Ma; Ruge Zang; Xiangxiu Wang; Chuan Chen; Xiaochen Kou; Yanhong Zhao; Jiayu Chen; Xuelian Liu; Jiaxu Lu; Ben Xu; Juntao Liu; Yanxin Huang; Chaoqun Chen; Hong Wang; Shaorong Gao; Yong Zhang; Yawei Gao ; ADNP modulates SINE B2-derived CTCFbinding sites during blastocyst formation in mice, GENES & DEVELOPMENT, 2024, DOI:10.1101/gad.351189.1

7. Wang C*, Liu X*, Gao Y*#, Yang L, Li C, Liu W, Chen C, Kou X, Zhao Y, Chen J, Wang Y, Le R, Wang H, Duan T, Zhang Y#, Gao S#.Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nat Cell Biol. 2018 May;20(5):620-631. doi: 10.1038/s41556-018-0093-4. 

8. Gao Y*, Chen J*, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T, and Gao S Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming Cell Stem Cell , 2013. 12(4): p. 453-69. 封面论文

9. Gao, Rui*, Wang, Chenfei*, Gao, Yawei*, Xiu, Wenchao, Chen, Jiayu, Kou, Xiaochen; Zhao, Yanhong; Liao, Yuhan; Bai, Dandan; Qiao, Zhibin; Yang, Lei; Wang, Mingzhu; Zang, Ruge; Liu, Xiaoyu; Jia, Yanping; Li, Yanhe; Zhang, Yalin; Yin, Jiqing; Wang, Hong; Wan, Xiaoping; Liu, Wenqiang#; Zhang, Yong#; Gao, Shaorong#Inhibition of Aberrant DNA Re-methylation Improves Post-implantation Development of Somatic Cell Nuclear Transfer Embryos Cell Stem Cell, 2018.9.6, 23(3): 426~435. 

10. Chuan Chen*, Wenqiang Liu*, Jiayin Guo, Yuanyuan Liu, Xuelian Liu, Jun Liu, Xiaoyang Dou, Rongrong Le, Yixin Huang, Chong Li, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, You Wu, Jiayu Chen, Hong Wang, Bin Shen#, Yawei Gao# & Shaorong Gao# 

Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos. Protein Cell 12, 455–474 (2021). 封面论文

11. Yawei Gao*, Xiaoyu Liu*, Bin Tang*, Chong Li*, Zhaohui Kou, Lin Li, Wenqiang Liu, You Wu, Xiaochen Kou, Jingyi Li, Yanhong Zhao, Jiqing Yin, Hong Wang, She Chen, Lujian Liao#, and Shaorong Gao#Protein Expression Landscape of Mouse Embryos during Pre-implantation Development Cell Reports 2017.12.26, 21(13): 3957~3969 

12. You Wu, Wenqiang Liu, Jiayu Chen, Shuaitong Liu, Mingzhu Wang, Lei Yang, Chuan Chen, Meijie Qi, Yiwen Xu, Zhibin Qiao, Rushuang Yan, Xiaochen Kou, Yanhong Zhao, Bin Shen, Jiqing Yin, Hong Wang, Yawei Gao# and Shaorong Gao#  Nuclear Exosome Targeting Complex Core Factor Zcchc8 Regulates the Degradation of LINE1 RNA in Early Embryos and Embryonic Stem Cells Cell Reports. 2019 Nov 19;29(8):2461-2472